Hadjod is a single-herb formulation prepared from the stem extract of Hadjod (Cissus quadrangularis). Hadjod ensures early ossification and proper remodeling of bones and is recommended for fracture healing. Hadjod accelerates the fracture-healing process by multiple mechanisms such as improving osteoblastic activity, early regeneration of connective tissue and restoring the normal composition of the bone. Hadjod mineralizes bone tissue and improves tensile strength through increased uptake of collagen, calcium, and phosphorus. Hadjod possesses anti-inflammatory action by inhibiting arachidonic acid metabolism by cyclooxygenase (COX) and lipoxygenase (LOX) pathways.
Pharmacological Actions
1. Fracture-healing activity
Hadjod contains vitamins and steroids, which are found to have a specific effect on bone fracture healing. These phytoconstituents show a marked influence on the rate of fracture healing by influencing early regeneration of all connective tissues involved in the healing and quick mineralization of callus. This hastening in fracture healing has been attributed to the stimulation of all cells of mesenchymal origin, namely, the fibroblasts, chondroblasts, and osteoblasts by Hadjod Thus Hadjod builds up the chemical composition of the fractured bone, namely, mucopolysaccharides, collagen, calcium, and phosphorus as well as its functional efficiency. Hadjod has been shown to cause an increase in the alkaline phosphatase level during fracture healing
Hadjod facilitates the bone formation and reduces bone loss by inhibiting the osteoclastic activity of tartrate-resistant acid phosphatase (osteoclastic marker).
2. Analgesic and anti-inflammatory activities
Hadjod has been proved to be highly effective in relieving pain, reducing swelling, and promoting the process of healing simple fractures as well as in curing the allied disorders associated with fractures. The constituents of Hadjod such as flavonoids and B-sitosterols inhibit the inflammatory process. Hadjod inhibits arachidonic acid metabolism by both COX and pathways. It acts by preventing the conversion of arachidonic acid to inflammatory prostaglandins.
3. Bone mineral density-improving activity
Systemic use of Hadjod is found to cause a complete restoration of the normal composition of bones. Hadjod acts by stimulating metabolism and increasing the uptake of calcium and sulfur. The increase in calcium deposition further helps join the broken segments of bones through the and early formation of collagen fibers. Early completion of the calcification process and remodeling phenomenon leads to faster recovery of fractures
4. Tensile strength-improving activity
Hadjod helps build tensile strength. Hadjod aids in building up the chemical composition of the fractured bone, namely mucopolysaccharides, collagen, calcium, and phosphorus. Alkaline phosphatase is involved in bone formation and the healing of fractures. The enzyme secreted by the osteoblasts accelerates the process of mineralization either by increasing the local concentration of inorganic phosphates or by activating the collagen fibers to induce the deposition of calcium salts.
Indications
- Traumatic fractures
- Pathological fractures
Due to the lack of safety data, the use of Hadjod during pregnancy and lactation is not recommended.
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