H & A Pharma Vasaka Tablets

 

Vasaka is a single-herb formulation prepared from the aerial part extract of Vasaka (Adhatoda vasica). Vasaka contains vasicine (parent compound of bromhexine) that liberates lysosomal enzymes involved in mucolytic action. Vasaka exhibits antitussive action by bronchial muscle relaxation or decreased airway resistance. Vasaka produces a significant anti-inflammatory effect on acute inflammatory processes by inhibiting cyclooxygenase (COX) and 5-lipoxygenase (5-LOX). Vasaka shows an immunomodulatory effect by inhibiting delayed-type hypersensitivity (DTH) reaction due to its influence on biological mediators such as histamine, products of arachidonic acid metabolism, and interferon (IFN)-y. The enzymatic antioxidant activity of Vasaka prevents chain initiation, binding of transition metal ion catalysts, reductive capacity, and radical scavenging.

Pharmacological Actions

1. Mucolytic and expectorant activities 

Bromhexine (N-methyl-N-cyclohexane-3,5-dibromo 2-aminobenzylamine hydrochloride) is derived from vasicine, an alkaloid from Vasaka. Bromhexine increases mucus secretion, reduces sputum viscosity, and facilitates expectoration.

Bromhexine liberates lysosomal enzymes into the cytoplasm. Lysosomal enzymes are involved in the mucolytic action on acid glycoprotein contained in the mucus granules of the submucosal gland. Bromhexine disintegrates the fibril in the sputum and lowers the viscosity of the mucus.

2. Antitussive and bronchodilatory activities

The antitussive activity of the pectic arabinogalactan obtained from Vasaka works by an antispasmodic or bronchodilatory action. Pectic arabinogalactan causes bronchial muscle relaxation in vitro or decreases airway resistance in vivo. Arabinogalactan possesses high cough-suppressive effect and decreases the values of specific airway resistance under in vivo conditions.

Vasicine shows inhibitory effect against carbachol, 5-hydroxytryptamine, and histamine-induced bronchoconstriction. The occupation of the receptor sites by vasicine molecules enhances the bronchodilatory effect of vasicine in vivo.

3. Anti-inflammatory activity

Vasaka produces significant anti-inflammatory activity in acute inflammatory processes.Vasaka has highest inhibitory effects on COX and 5-LOX, found among the class of phenolic compounds and arachidonic acid analogs. Both COX and 5-LOX are enzymes responsible for the formation of inflammatory mediators such as prostanoids and leukotrienes.

4. Immunomodulatory activity

Vasaka potentiates both humoral as well as cell mediated immunities. Vasaka inhibits DTH reactiveness. The interaction of sensitized T cells with the presented antigen is known to be associated with the release of mediators such as histamines. Products of arachidonic acid metabolism and IFN-y eventually lead to DTH. Therefore, the inhibitory action could be due to an influence of fraction on the biological mediators.

5. Antioxidant activity

The enzymatic and nonenzymatic antioxidants in Vasaka exhibit antioxidant and radical scavenging activities. The activity of enzymatic antioxidants such as superoxide dismutase, catalase, and ascorbic acid oxidase has been attributed to various mechanisms such as prevention of chain initiation, binding of transition metal ion catalysts, decomposition of peroxides, prevention of continued hydrogen abstraction, reductive capacity, and radical scavenging.

Indications

• Productive cough
• Cough associated with chronic obstructive pulmonary disease (COPD)
• Smoker's cough
• Bronchitis
• Asthma

H & A Pharma Manjishtha Tablets

 

Manjishtha is a single-herb formulation prepared from the root extract of Manjishtha (Rubia cordifolia). Manjishtha decreases melanin production and its deposition in the skin by inhibiting the tyrosinase enzyme, which leads to hyperpigmentation. Manjishtha shows significant anti-inflammatory activity by suppressing proinflammatory cytokines. Rubiacordone A (1) and anthraquinone (2), key constituents of Manjishtha, are found to have antimicrobial effects.

Pharmacological Actions

1. Hyperpigmentation

Melanin is synthesized by the enzyme tyrosinase. Pigmentation disorders arise as a result of increased production of melanin by melanocytes and/or elevated transfer of melanosomes from melanocytes to basal and suprabasal keratinocytes. By inhibiting the tyrosinase enzyme, melanin production and its deposition in the skin can be decreased. The tyrosinase enzyme is viewed as an important target for the treatment of hyperpigmentation disorders. Manjishtha inhibits the tyrosine enzyme.

2. Antimicrobial activity

Manjishtha has been shown to possess strong antibacterial and antifungal activities. Compounds such as rubiacordone A (1) and anthraquinone (2) of Manjishtha were found to have an antimicrobial effect against gram-positive bacteria, namely Bacillus subtilis, Streptococcus faecalis, and Bacillus cereus.

3. Anti-inflammatory activity

Manjishtha shows significant anti-inflammatory activity by suppressing reactive oxygen species and proinflammatory cytokines. Anthraquinone, a phenolic compound obtained from Manjishtha, exhibited significant anti-inflammatory activity.

4. Antioxidant activity

Rubidianin, an anthraquinone isolated from the extract of Manjishtha, has been demonstrated to prevent lipid peroxidation induced by ferrous sulfate and t-butylhydroperoxide. Thus, Manjishtha possesses significant antioxidant activity.

Indications

• Melasma
• Age spots

Unlock the Benefits of H&A Pharma Green Tea Tablets: Your Instant Source of Natural Wellness

 

Green tea is touted to be one of the healthiest beverages on the planet.

It’s loaded with antioxidants that have many health benefits, which may include:

• Improved brain function
• Fat loss
• Protecting against cancer
• Lowering the risk of heart disease

There may be even more potential health benefits. People used green tea in traditional Chinese and Indian medicine to control bleeding and heal wounds, aid digestion, improve heart and mental health, and regulate body temperature.

In today's fast-paced world, it can be challenging to find time to prioritize our health and well-being. However, with H&A Pharma Green Tea Tablets, you can conveniently incorporate the power of natural ingredients into your daily routine. This instant-water dissolve tablets are packed with a carefully curated blend of ingredients, including Garcinia Cambogia, Green Tea Extract, Cinnamon Extract, Tulsi Extract, Lemon Extract, Ginger Extract, Piper Nigrum, and Black Salt. In this blog post, we will explore the incredible benefits of these ingredients and how they work synergistically to support your overall wellness.

Garcinia Cambogia (100 mg)

Garcinia Cambogia is a tropical fruit known for its potential weight management benefits. It contains hydroxy citric acid (HCA), which may help suppress appetite and inhibit the production of fat in the body. By incorporating Garcinia Cambogia into H&A Pharma Green Tea Tablets, this product aims to support your weight management goals.

Camellia sinensis (Green Tea Extract) (200 mg)

Green tea has been celebrated for centuries for its numerous health benefits. Rich in antioxidants, particularly catechins, green tea extract helps protect the body against oxidative stress. It may also boost metabolism, promote fat oxidation, and contribute to healthy weight management. Additionally, green tea extract may assist in maintaining cardiovascular health and supporting a healthy immune system.

Cinnamon Extract (25 mg)

Cinnamon is not only a delightful spice but also boasts impressive health properties. It has been associated with balancing blood sugar levels and enhancing insulin sensitivity, making it a valuable addition for individuals concerned about maintaining healthy blood sugar levels. Moreover, cinnamon extract may help support healthy digestion and reduce inflammation.

Tulsi Extract (25 mg)

Tulsi, also known as Holy Basil, is highly regarded in Ayurvedic medicine for its adaptogenic and immune-boosting properties. It is believed to help combat stress and promote relaxation. Tulsi extract included in H&A Pharma Green Tea Tablets can potentially support a healthy response to stress and contribute to overall mental well-being.

Lemon Extract (25 mg):

Lemons are known for their refreshing taste and high vitamin C content. Vitamin C is a powerful antioxidant that aids in neutralizing free radicals and supporting a robust immune system. The inclusion of lemon extract in these tablets adds a citrusy flavor while providing an additional boost of this vital nutrient.

Ginger Extract (25 mg):

Ginger has been used traditionally for its digestive benefits. It may help soothe an upset stomach, reduce nausea, and support healthy digestion. Ginger extract is incorporated into these tablets to provide a natural way to support gastrointestinal wellness.

Piper Nigrum (25 mg)

Piper Nigrum, commonly known as black pepper, contains an active compound called piperine. Piperine has been shown to enhance the bioavailability and absorption of various nutrients, making it an excellent addition to this formulation. By including Piper Nigrum in H&A Pharma Green Tea Tablets, the product aims to maximize the benefits of the other ingredients.

Black Salt (5 mg):

Black salt, also known as Kala Namak, is a type of rock salt with a distinctive sulfurous flavor. It is commonly used in Ayurvedic medicine for its potential digestive benefits. The addition of black salt to these tablets enhances the taste while providing a touch of traditional wisdom.

H&A Pharma Green Tea Tablets offer a convenient and effective way to harness the power of natural ingredients for your overall wellness. From Garcinia Cambogia for weight management to Green Tea Extract for antioxidants and metabolism support, these tablets are carefully formulated

Directions for Use:

1. Take one H&A Pharma Green Tea Tablet.
2. Fill a cup or mug with hot water.
3. Drop the tablet into the hot water.
4. Allow the tablet to dissolve completely, stirring if necessary.
5. The tablet will release green tea and other natural ingredients, infusing the water with their beneficial properties.
6. Once the tablet has dissolved, your green tea is ready to enjoy.
7. You may adjust the strength of the tea by adding more or less water according to your preference.
8. Optionally, you can add sweeteners like honey or lemon for added flavor.
9. Sit back, relax, and savor the delightful taste and health benefits of H&A Pharma Green Tea.

Note: These instant-dissolve tablets are designed as a convenient alternative to traditional tea bags. They provide a quick and hassle-free way to enjoy a cup of green tea with the added benefits of other natural ingredients. Remember to store the tablets in a cool, dry place and ensure the package is properly sealed after each use to maintain their freshness.

As with any dietary supplement, it is advisable to consult with a healthcare professional if you have any specific health concerns or are taking medications.

Enjoy the convenience and goodness of H&A Pharma Green Tea Tablets as a refreshing and nourishing replacement for your regular tea bags.

H & A Pharma Tagara Tablets

Tagara is a single-herb formulation prepared from the rhizome extract of Tagara (Valeriana wallichii). Tagara exhibits sedative effect due to the presence of hesperidin (HN), a natural flavanone glycoside.

Tagara contains 6-methyl apigenin (MA) that brings about anxiolytic activity by acting as a ligand for the benzodiazepine-binding site (BZD-bs). Tagara exhibits an antidepressant property by activating y-aminobutyric acid-A (GABA-A) receptors. 

Pharmacological Actions

1. Restores circadian rhythm

5-Hydroxytryptamine-5a (5-HT) receptor is distributed throughout the brain. The receptor concentrations are particularly intense in the suprachiasmatic nucleus of the hypothalamus, the site of the biological clock that drives circadian rhythms. Serotonin is well known to modulate sleep wake cycles and circadian rhythms in the human brain through a G-protein-coupled receptor family. Valerian and valerenic acids of V wallichii are new partial agonists of the 5-HT receptor. Release of 5-HT during the sleep-wake cycle initiates a cascade of genomic events in some hypnogenic neurons located in the preoptic area and the neighboring suprachiasmatic nucleus including vasoactive intestinal polypeptide and GABAergic mechanism.

2. Sedative activity

The sedative effect of V wallichii is due to its natural flavanone glycoside 2S(-)-7-rhamnoglucosyl hesperetin or HN.2 The sedative activity of HN is potentiated by simultaneous administration of valerenic acid.³ MA has been proved to have medium to high affinity for the BZD-bs, as a result of which it reduces excitement and produces calmness.

3. Anxiolytic activity

MA isolated from V wallichii has the ability to bring about an anxiolytic effect. MA is a natural flavonoid derivative that serves as a ligand for the BZD-bs of the GABA-A receptor; it has a high affinity for BZD-bs. MA has thus, been able to potentiate the sleep enhancing property of HN.

4. Antidepressant activity

The antidepressant property of V wallichii is due to the activation of GABA-A receptors, which are molecular substrates for the regulation of vigilance and anxiety. Several terpenoid GABA derivatives are known to induce inherent antidepressant action.

Indications

• Disturbed sleep
• Insomnia