H & A Pharma Flax Seed Capsule
H & A Pharma Punarnava Tablets
Punarnava is a single-herb formulation prepared from the root extract of Punarnava (Boerhaavia diffusa). Punarnava has antimicrobial and diuretic properties and is recommended in the management of urinary tract infections (UTIs) and associated symptoms. Punarnava contains glycoproteins that have antibacterial activity against RNA bacteriophages. Punarnava possesses diuretic action, which can be attributed to its constituent ẞ-ecdysone, a xanthone, which inhibits the kidney's succinic dehydrogenase. Punarnava brings about anti-inflammatory action by inhibiting the release of proinflammatory mediators and prostaglandin synthesis.
Pharmacological Actions
1. Antimicrobial activity
2. Anti-inflammatory activity
Punarnava possesses a dose-dependent anti-inflammatory activity. It stabilizes the cell membrane, thereby inhibiting cell lysis and the release of proinflammatory mediators. During inflammation, lysosomal hydrolytic enzymes are released, and this damages the surrounding organelles and tissues, resulting in a variety of disorders. Inflammation is mediated through the release of mediators including vasoactive substances such as histamine, bradykinin, serotonin, and prostaglandins. These chemicals promote the accumulation of fluid in the tissues and thus edema. Therefore, the mode of action of Punarnava extract is possibly through the prevention of the release of proinflammatory mediators and inhibition of prostaglandin synthesis, which further results in the inhibition of inflammation.
3. Diuretic activity
Punarnava has potent diuretic activity. The diuretic activity of Punarnava can be attributed to the potassium and B-ecdysone content in it. It stimulates d-amino acid oxidase and inhibits succinic dehydrogenase in the kidney, thereby resulting in diuretic action.
Indications
- UTI
- UTI in pregnancy
H & A Pharma Yastimadhu Tablets
Yashtimadhu is a single-herb formulation prepared from the root extract of Yashtimadhu (Glycyrrhiza glabra). Yashtimadhu has demulcent and emollient actions and is recommended in the management of acid peptic disorders including non-ulcer dyspepsia. Yashtimadhu promotes the healing of gastric and duodenal ulcers by reducing basal and histamine-induced gastric acid secretion. Yashtimadhu consists of glabridin and glabrene, which exhibit inhibitory activity against the growth of Helicobacter pylori. Glycyrrhizin (as carbenoxolone sodium) increases pH at the stomach antrum, reduces reflux, improves the way food gets through to the stomach, and protects the walls of the esophagus. Yashtimadhu has a soothing property and is used as demulcent-it acts on the mucosal layer corticoster and increases the production of mucus, thus accelerating the healing of gastric and duodenal ulcers.
Pharmacological Actions
1. Gastric secretion-inhibitory activity
Glycyrrhizin (as carbenoxolone sodium) obtained from Yashtimadhu speeds the healing of gastric ulcers and protects the gastric mucosa by increasing the pH at the stomach antrum from 1.1 to 6.0 and reduces basal and histamine-induced gastric acid secretion.
2. Mucoprotective activity
Deglycyrrhizinated licorice, a derivative of glycyrrhizic acid (GA), a component of Yashtimadhu is used in the treatment of ulcers as it promotes healing by increasing mucus production and blood supply to the damaged stomach mucosa.
3. Helicobacter pylori-inhibitory activity
Yashtimadhu consists of chemical constituents such as glabridin and glabrene, which exhibit inhibitory activity against the growth of H pylori. These flavonoids also exhibit the anti-H pylori activity against a clarithromycin-resistant and amoxicillin-resistant strain.2 Orally administered glycyrrhizin is converted into the active metabolite GA by human intestinal bacteria through B-glucuronidase. GA is found to be the most active constituent in inhibiting H pylori.
4. Antireflux activity
Yashtimadhu is used to treat GERD because of its soothing property. Yashtimadhu reduces reflux by protecting the mucosal layers from the harmful effects of stomach acid, improving the way food gets through to the stomach, and protecting the walls of the esophagus.
5. Demulcent activity
Yashtimadhu has a soothing property and is used as a demulcent to promote the healing of gastric and duodenal ulcers. It acts on the mucosal layer and increases the production of mucus, thus accelerating the healing of gastric and duodenal ulcers.
Indications
- Acid peptic disorders
- Ulcers and non-ulcer dyspepsia
- Drug-induced gastritis
- Gastroesophageal reflux disease (GERD)
- Heartburn
Disclaimer: Always consult with a healthcare professional before starting any new supplement regimen, especially if you have any pre-existing health conditions or are taking other medications.
H & A Pharma Neem Tablets
Neem is a single-herb formulation prepared from the leaf extract of Nimba (Azadirachta indica). Neem has antimicrobial, anti-inflammatory, and immunomodulatory properties and is recommended in the management of various skin allergies and infections. Neem, with its antibacterial property, effectively inhibits the growth of Propionibacterium acnes. Neem by virtue of its anti-inflammatory activity inhibits Prese inflammatory mediators such as 5-hydroxytryptamine (5-HT), histamine, bradykinin, and prostaglandin (PG) E1. Neem helps fight acne and skin allergies. Neem boosts both lymphocytic and cell-mediated immune responses. Neem has antioxidant activity and thus helps protect cells from free radical damage.
Pharmacological Actions
1. Antimicrobial activity
2. Anti-inflammatory activity
3. Antiallergic activity
5. Antioxidant activity
Indications
- Acne vulgaris
- Skin allergies and infections
H & A Pharma Meshashringi Tablets
Meshashringi is a single-herb formulation prepared from the leaf extract of Meshashringi (Gymnema sylvestre). Meshashringi has insulinotropic activity and is recommended in the management of impaired glucose tolerance. Meshashringi contains gymnemic acid molecules, which are similar to that of glucose molecules. Gymnemic acid molecules reduce sugar cravings by filling the receptor locations on the taste buds. Meshashringi reduces the glucose level by promoting the regeneration of islet cells and increasing insulin secretion through its insulinotropic activity.
Pharmacological Actions
1. Inhibits sugar craving
The gymnastic acid molecules present in Meshashringi have an atomic arrangement similar to that of glucose molecules. These molecules fill the receptor locations on the taste buds, thereby preventing its activation by sugar molecules present in the food, and thus curbing sugar craving.'
Meshashringi (sugar destroyer) has the property of abolishing the taste of sugar. Studies suggest that extracts from the leaves of Meshashringi help improve sugar assimilation. The active principles include a glycoside mixture, gymnemic acids, and gurmarin (a peptide), which inhibit the sweet taste response in mammals.
2. Antidiabetic activity
Meshashringi has been found to possess hypoglycemic properties and is used in herbal formulations prescribed in the management of type 2 diabetes in adults. When Meshashringi extract is administered to a patient with type 2 diabetes, the pancreas is stimulated, which results in increased insulin release. Some possible mechanisms by which the leaf extract of Meshashringi (gymnemic acid) brings about its hypoglycemic effects are by
- promoting regeneration of islet cells,
- increasing secretion of insulin,
- inhibiting glucose absorption from the intestine, and • promoting glucose utilization.
Meshashringi reduces urine glucose in diabetics. Meshashringi is effective in lowering fasting as well as postprandial blood glucose levels.
Gymnemic acids have the ability to delay glucose absorption in the blood by filling the receptor location in the absorptive external layers of the intestine and preventing the absorption of sugar molecules by the intestine, which in turn results in lowering the blood sugar level.'
Meshashringi has a-glucosidase inhibitory activity. a-Glucosidase inhibitors are saccharides that act as competitive inhibitors of enzymes needed to digest carbohydrates, specifically a-glucosidase enzymes present in the brush border of the small intestine. The membrane-bound intestinal a-glucosidases hydrolyze oligosaccharides, trisaccharides, and disaccharides to glucose and other monosaccharides in the small intestine. Inhibition of these enzyme systems reduces the rate of digestion of carbohydrates. Consequently, less glucose is absorbed because the carbohydrates a s are not broken down into glucose molecules.2
Meshashringi increases the utilization of glucose by increasing the activities of the enzymes responsible for the utilization of glucose through insulin-dependent pathways increasing phosphorylase levels and decreasing gluconeogenic enzymes and sorbitol dehydrogenase levels.3
Meshashringi promotes the regeneration of islet cells and helps in controlling blood sugar levels.4 Supplementation of Meshashringi in patients with type 2 diabetes may result in either the regeneration or repair of ẞ cells, which is indicated by the post-supplementation rise in serum insulin level Meshashringi stimulates insulin secretion from ẞ cells and human islets. It stimulates an increase in Ca²* influx in ẞ cells; these elevations in Ca2+ contribute to the enhanced secretory output. This demonstrates that G sylvestre has direct insulin secretagogue or insulinotropic effects on human islets.
Indications
• Prediabetes (impaired glucose tolerance)
As a co-prescription in
- Type 2 diabetes
- Diabetes associated with obesity
Disclaimer: Always consult with a healthcare professional before starting any new supplement regimen, especially if you have any pre-existing health conditions or are taking other medications.
H & A Pharma AYUR-C
Pharmacological Actions of Each ingredients
Orange Extract:
Amalaki Extract:
Lemon Extract:
Kiwi Extract:
Acerola Cherry:
Zinc:
Hacid -SF
What is acid peptic disease?
Acid peptic disease – commonly called APD – includes a number of conditions. All these conditions are the result of damage from acid and peptic activity in gastric secretions. APD occurs when the acid starts irritating the inner cells (mucosal layer) of the stomach. Acid peptic diseases mostly affect the esophagus, stomach, and duodenum.
Acid peptic diseases are caused by the excessive presence of acid and pepsin. The two main types of acid-peptic diseases are gastric and duodenal ulcers. However, they can also occur at the GJ Stoma, the lower end of the esophagus, and Meckel’s diverticulum. According to the duration and complexity of symptoms they can be acute or chronic.
What are the symptoms of the acid peptic disease?
A digestive function disorder, the acid peptic disease is characterized by dyspepsia (discomfort, heartburn, or nausea). However, the classic symptom of peptic ulcer disease, is defined as pain centered in the upper abdomen or discomfort characterised by fullness, bloating, distention, or nausea. Factors contributing to acid peptic disorder Acid peptic disorder results when the balance between the aggressive and defensive factors in the gastroduodenal mucosa is disrupted. This balance could be disrupted by factors such as H pylori infection, NSAID (Non-steroidal anti-inflammatory drug), and acid secretory abnormalities. A defect in bicarbonate production and acid neutralisation in the duodenal bulb is also a potent cause.
Factors that lead to acid peptic disorder
- Smoking
- Alcohol
NSAIDs including aspirin - Foods
- Citrus or acidic fruits
- Chocolate, caffeine, and alcohol
- Greasy, fatty, spicy, and fried foods
- Garlic, onions, and mint flavourings
- Drugs, such as aspirin and types of steroids
- Helicobacter pylori
Hyperacidity and its signs &t symptoms?
Hyperacidity, also known as acid dyspepsia, is the excessive acid secretion that causes irritation and inflammation of the internal lining of the stomach.
Signs and symptoms of hyperacidity include:
- Burning sensation in the chest and stomach
- Bloating
- Belching
- Sour eructation
- Nausea, along with occasional vomiting
- Indigestion
What are the causes of hyperacidity?
- Overeating or eating fatty/spicy foods
- Overconsumption of coffee or tea
- Irregular eating habits
- Smoking
- Emotional stress and worry
Composition
Clinical Pharmacology
Pharmacological actions of principal ingredients
Cytoprotective and ulcer-healing actions
Antioxidant action:
Tej pattar (Cinnamomum tamala) , Pudina satwa (Mentha pipereta), Jaiphal (Myristica fragrans) have antioxidant activities that protect from free radical scavenging of the gastric mucosa.
Antacid and antiflatulent actions:
Sajji kshar is an antacid used in the symptomatic treatment of hyperacidity, indigestion, and heartburn.
Ajwain (Trychyspermum ammi) is an antacid that complements the actions of other constituents with its cooling and antiflatulent properties. It treats hyperacidity.
Yashtimadhu relieves the burning pain of NUD and peptic ulcers and reduces hyperacidity by neutralizing gastric acid.
Hacid SF
For symptomatic management of Acid peptic disease (APD) Non-ulcer dyspepsia (NUD) Gastroesophageal reflux disease (GERD) Heartburn NSAID-induced gastritis
₹95
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