H & A Pharma Neem Tablets

 

Neem is a single-herb formulation prepared from the leaf extract of Nimba (Azadirachta indica). Neem has antimicrobial, anti-inflammatory, and immunomodulatory properties and is recommended in the management of various skin allergies and infections. Neem, with its antibacterial property, effectively inhibits the growth of Propionibacterium acnes. Neem by virtue of its anti-inflammatory activity inhibits Prese inflammatory mediators such as 5-hydroxytryptamine (5-HT), histamine, bradykinin, and prostaglandin (PG) E1. Neem helps fight acne and skin allergies. Neem boosts both lymphocytic and cell-mediated immune responses. Neem has antioxidant activity and thus helps protect cells from free radical damage.

 Pharmacological Actions 

1. Antimicrobial activity

Neem has been shown to possess moderate inhibitory activity against acne-inducing bacteria such as P acnes.¹ Neem has antibacterial activity against both gram-positive and gram-negative bacteria, viruses, and other eukaryotic microorganisms. An in vitro study has shown that Neem inhibits the growth of Candida albicans,

2. Anti-inflammatory activity

Neem is found to have an inhibitory effect on the action of chemical mediators such as 5-HT and PGE1. This inhibitory effect might be due to the stabilization of lysosomal membranes and antiproliferative effect."

P acnes plays an important role in the pathogenesis of acne inflammation by inducing polymorphonuclear leukocytes (PMNL) and monocytes and/or macrophages to produce proinflammatory mediators. These organisms produce neutrophil chemotactic factors, which attract neutrophils to release inflammatory mediators, such as reactive oxygen species (ROS) and lysosomal enzymes, resulting in disruption of the integrity of the follicular epithelium. ROS are considered to be one of the most potent stimuli for inflammation. They also stimulate monocytes/macrophages for increased production of proinflammatory cytokines such as tumor necrosis factor (TNF)-a, interleukin (IL)-8, and IL-1ẞ.Neem exhibits anti-inflammatory property by inhibiting the production of ROS from PMNL and proinflammator cytokines (IL-8 and TNF-a) in human peripheral blood mononuclear cells.

3. Antiallergic activity

The antiallergic effect of  Neem is shown by its bronchoprotective, mast cell degranulation, and active anaphylaxis roles. 4. Immunomodulatory activity

Neem boosts both lymphocytic and cell-mediated immune responses, including killer T cells, which destroy microbes, viruses, and cancer cells by infusing toxic chemicals into the invaders."

 5. Antioxidant activity

Neem possesses antioxidant activity, which helps protect from damage due to free radicals. Studies have found that  Neem provides protection against chemically induced carcinogens by boosting antioxidant levels.

Indications

• Acne vulgaris
• Skin allergies and infections

Disclaimer: Always consult with a healthcare professional before starting any new supplement regimen, especially if you have any pre-existing health conditions or are taking other medications.