H & A Pharma Punarnava Tablets

 

Punarnava is a single-herb formulation prepared from the root extract of Punarnava (Boerhaavia diffusa). Punarnava has antimicrobial and diuretic properties and is recommended in the management of urinary tract infections (UTIs) and associated symptoms. Punarnava contains glycoproteins that have antibacterial activity against RNA bacteriophages. Punarnava possesses diuretic action, which can be attributed to its constituent ẞ-ecdysone, a xanthone, which inhibits the kidney's succinic dehydrogenase. Punarnava brings about anti-inflammatory action by inhibiting the release of proinflammatory mediators and prostaglandin synthesis.

Pharmacological Actions

1. Antimicrobial activity

The purified glycoprotein from Punarnava exhibits strong antimicrobial activity against RNA bacteriophages.

The antimicrobial activity of potassium and B-ecdysone content in it. It stimulates d-amino acid oxidase and inhibits succinic dehydrogenase in the kidney, thereby resulting in diuretic action. can be attributed to its constituent alkaloids, saponins, flavonoids, polysaccharides, steroids, and tannins. It has been shown to produce zones of inhibition of both gram-positive and gram-negative bacterial strains. In an in vitro study, potassium and B-ecdysone content in it. It stimulates d-amino acid oxidase and inhibits succinic dehydrogenase in the kidney, thereby resulting in diuretic action. was shown to inhibit the growth of Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae, Staphyllococcus aureus, and Streptococcus.

2. Anti-inflammatory activity

Punarnava possesses a dose-dependent anti-inflammatory activity. It stabilizes the cell membrane, thereby inhibiting cell lysis and the release of proinflammatory mediators. During inflammation, lysosomal hydrolytic enzymes are released, and this damages the surrounding organelles and tissues, resulting in a variety of disorders. Inflammation is mediated through the release of mediators including vasoactive substances such as histamine, bradykinin, serotonin, and prostaglandins. These chemicals promote the accumulation of fluid in the tissues and thus edema. Therefore, the mode of action of Punarnava extract is possibly through the prevention of the release of proinflammatory mediators and inhibition of prostaglandin synthesis, which further results in the inhibition of inflammation.

3. Diuretic activity

Punarnava has potent diuretic activity. The diuretic activity of Punarnava can be attributed to the potassium and B-ecdysone content in it. It stimulates d-amino acid oxidase and inhibits succinic dehydrogenase in the kidney, thereby resulting in diuretic action.

Indications

• UTI
• UTI in pregnancy

Disclaimer: Always consult with a healthcare professional before starting any new supplement regimen, especially if you have any pre-existing health conditions or are taking other medications.